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Medical uses[ edit ] The main use of linezolid is the treatment of severe infections caused by aerobic Gram-positive bacteria that Zyvox Suffisant resistant to other antibiotics; it should not be used against bacteria that are sensitive to drugs with a narrower spectrum of activity, such as penicillins and cephalosporins.
In both the popular press and the scientific literature, Zyvox Suffisant, linezolid has been called a “reserve antibiotic”—one that should be used sparingly so that it will remain effective as a drug of last resort against potentially intractable infections.
Food and Drug Administration FDA are the treatment of vancomycin-resistant Enterococcus faecium infectionswith or Zyvox Suffisant bacterial invasion of the bloodstream ; nosocomial pneumonia hospital-acquired and community-acquired pneumonia caused by S.
Several issues in Zyvox Suffisant design have been raised, however, calling into question results that suggest the superiority of linezolid. The patient received conventional treatment, with ampicillinimipenemand glucocorticoidsand recovered fully after heart surgery. Nevertheless, preclinical studies were conducted Zyvox Suffisant assess the efficacy of linezolid for these infections,  and the drug has been used successfully to treat them in clinical practice.
Linezolid appears to be a reasonable therapeutic option for infective endocarditis caused by multi-resistant Gram-positive bacteria, despite a lack of high-quality evidence to support this use.
In adults, daily and twice-daily dosing have been used to good effect. Many months of treatment are often required, and the rate of adverse effects is high Zyvox Suffisant of dosage. Again, there is little evidence for its use in this setting, as infectious endophthalmitis is treated widely and effectively with vancomycin injected directly into the eye, Zyvox Suffisant.
Nonetheless, it has been used successfully in many cases of central nervous system infection—including meningitis—caused by susceptible bacteria, Zyvox Suffisant, and has also been suggested as a reasonable choice for this indication when treatment options are limited or when other antibiotics have failed, Zyvox Suffisant. Patients treated with vancomycin could be switched to oxacillin or dicloxacillin if the bacteria that caused their infection was found to be susceptible, and patients in both groups linezolid and vancomycin could receive specific treatment against Gram-negative bacteria if necessary.
When data from all participants were pooled, the study found that In participants whose infection was due to Gram-positive bacteria alone, Zyvox Suffisant, linezolid was as safe and effective as vancomycin.
Pseudomonas and the Enterobacteriaceaefor instance, are not susceptible.
Linezolid is the only one that can be taken by mouth for the treatment Zyvox Suffisant systemic infections.
The protocol includes twice-weekly blood tests and liver function tests ; measurement of serum lactate levels, Zyvox Suffisant, for early detection of lactic acidosis; a review Zyvox Suffisant all medications taken by the patient, interrupting the use of those that may interact with linezolid; and periodic eye and neurological exams in patients set to receive linezolid for longer than four weeks, Zyvox Suffisant. Bone marrow suppression Zyvox Suffisant not identified during Phase III trials, in which treatment did not exceed 21 days.
Although some participants of early trials did experience thrombocytopenia, it was found to be reversible and did not occur significantly more frequently than in controls participants not taking linezolid.
There have been postmarketing reports of serotonin syndrome when linezolid was given with or soon after the discontinuation of serotonergic drugs, Zyvox Suffisant, particularly selective serotonin reuptake inhibitors such as paroxetine and sertraline.
Linezolid does not inhibit or induce the cytochrome P CYP system, which is responsible for the metabolism of many commonly used drugs, and therefore does not have any CYP-related interactions.